Forschung:
Durch patientenorientierte klinische Studien und Grundlagenforschung können Pankreastumore erforscht und die Behandlung stetig verbessert werden.
Am Pankreaszentrum Marburg wird ausgiebig in nationalen und internationalen Forschungsverbünden zu endokrinen und exokrinen Pankreastumoren geforscht.
Viele Forschungsvorhaben werden aufgrund ihrer hohen Qualität z.B. durch die Deutsche Forschungsgemeinschaft (DFG), die EU und die Deutsche Krebshilfe gefördert.
Zudem steht unserem Forschungslabor ein transgenes Tumormausmodell zu Verfügung, das erstmalig die Entstehung des humanen Pankreaskarzinoms widerspiegelt.
Einen Überblick gibt die Auflistung der wichtigsten Publikationen aus den letzten vier Jahren:
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Bartsch DK, Langer P, Habbe N, Matthei E, Chaloupka B, Sina M, Gress TM, Slater EP.
Clinical and genetic analysis of 18 pancreatic carcinoma-melanoma prone families.
Br J Cancer, eingereicht -
Fendrich V, Chen NM, Neef M, Waldmann J, Buchholz M, Feldmann G, Slater EP, Maitra A, Bartsch DK.
The Angiotensin-I-converting Enzyme Inhibitor Enalapril and Aspirin delay progression of Pancreatic Intraepithelial Neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
Gut, eingreicht. -
Slater EP, Langer P, Habbe N, Fendrich V, Chaloupka B, Matthäi E, Hahn SA, Bartsch DK.
Prevalence of BRCA2 and CDKN2a mutations in familial pancreatic cancer.
Int. J. Cancer, eingereicht -
Langer P, Kann PH, Fendrich V, Habbe N, Schneider M, Sina M, Slater EP, Heverhagen JT, Gress TM, Bartsch DK.
Familial pancreatic cancer - results of 5 years prospective screening of high risk individuals.
Gut, in Druck -
Habbe N, Koorstra J-BM, Mendell JT, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG, Hong S-M, Maitra A
MicroRNA miR-155 is a biomarker of early pancreatic neoplasia.
Cancer Biol Ther Mar 3;8(4) (2009) -
Habbe N, Langer P, Bartsch DK.
Hereditary pancreatic cancer.
Chirurg 79:1029-37, (2008) -
Fendrich V, Esni F, Garay MV, Feldmann G, Habbe N, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD, Maitra A.
Hedgehog signaling regulates facultative progenitor activity in regenerating exocrine pancreas.
Gastroenterology 135:621-631(2008) -
Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C, Bardeesy N, Ouellette MM, Yu W, Maitra A.
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.
Gut 57:1420-30 (2008). -
Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, Koorstra JB, Habbe N, Karikari C, Mullendore M, Gabrielson KL, Sharma R, Matsui W, Maitra A.
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Mol Cancer Ther 7:2725-35 (2008). -
Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, Karikari C, Alvarez H, Iacobuzio-Donahue C, Jimeno A, Gabrielson KL, Maitra A.
Hedgehog signalling modulates the invasive phenotype of human pancreatic cancer - Implications for therapy of metastatic disease.
Cancer Res 67:2187-96 (2007) -
Aleksic T, Bechtel M, Krndija D, von Wichert G, Knobel B, Giehl K, Gress TM, Michl P.
CUTL1 promotes tumor cell migration by decreasing proteasome-mediated Src degradation.
Oncogene 26(40):5939-49 (2007) -
Ripka S, König A, Buchholz M, Wagner M, Sipos B, Klöppel G, Downward J, Gress T, Michl P.
WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer.
Carcinogenesis. 2007 Jun;28(6):1178-87 (2007) -
Neesse A, Wagner M, Ellenrieder V, Bachem M, Gress TM, Buchholz M.
Pancreatic stellate cells potentiates proinvasive effects of serpine E2 expression in pancreatic cancer xenograft tumors.
Pancreatology 14: 380-3985 (2007) -
Jungert K, Buck A, Buchholz M, Adler G, Gress T, Ellenrieder V.
Sp1 is required for TGFbeta-induced EMT and migration in pancreatic cancer.
Cancer Research 67: 1563-1570 (2007) -
Slater E, Amrillaeva V, Bartsch DK et al.
Palladin mutation causes familial pancreatic cancer: absence in European families
PLoS Med.4:e16 (2007) -
Langer P, Rothmund M, Bartsch DK
Prophylaktische Chirurgie des Pankreas.
Chirurg 77: 25-32 (2006) -
Buchholz M , Schatz A, Michl P, Linhart T, Adler G, Gress T, Ellenrieder V.
Oncogenic overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFAT2.
EMBO J 25: 3714-372 (2006) -
Buck A, M. Buchholz, G. Adler, T. Gress and V. Ellenrieder.
A novel mechanism in TGFß-induced growth inhibition that is lost in pancreatic cancer.
Mol Cancer Res 4: 862-871 (2006) -
Jungert K, Buck A, Buchholz M, Wagner M, Adler G, Gress T, Ellenrieder V.
Smad-Sp1 complexes mediate TGF -induced early transcription of oncogenic Smad7 in pancreatic cancer cells.
Carcinogenesis 27: 2392-2401 (2006) -
Habbe N, Langer P, Sina-Frey M, Bartsch DK.
Familial pancreatic cancer syndromes.
Endocrinol Metab Clin North Am 35: 417-430 (2006) -
McFaul CD, Earl J, Howes N, Neoptolemos JP, Greenhalf W for the European Registry of Hereditary Pancreatis and familial Pancreatic Cancer (EUROPAC) and Kress R., Sina-Frey M, Rieder H, Hahn SA, Bartsch DK for the German National Case Collection of Familial Pancreatic Cancer (FaPaCa).
Anticipation in familial pancreatic cancer.
Gut 55: 252-258 (2006) -
Earl J, Yan L, Vitone LJ, Risk J, Kemp SJ, McFaul C, Neoptolemos JP, Greenhalf W; European Registry of hereditary pancreatitis and familial pancreatic cancer, Kress R, Sina-Frey M, Hahn SA, Rieder H, Bartsch DK; German national cases Collection for Familial Pancreatic Cancer.
Evaluation of the 4q32-34 locus in European familial pancreatic cancer.
Cancer Epidemiol Biomarkers Prev 15: 1948-1955 (2006) -
Bartsch DK, Fendrich V, Slater EP, Sina-Frey M, Rieder H, Greenhalf W, Chaloupka B, Hahn SA, Neoptolemos JP, Kress R.,
RNASEL germline variants are associated with pancreatic cancer.
Int J Cancer 117: 718-722 (2005) -
Buchholz M, Kestler HA, Holzmann K, Ellenrieder V, Schneiderhan W, Siech M, Adler G, Bachem MG, Gress T.
Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype.
J Mol Med. 83:795-805 (2005) -
Fendrich V, Slater EP, Heinmöller E, Ramaswamy A, Celik I, Nowak O, Chaloupka B, Gerdes B, Bartsch DK.
Alterations of the TIMP3 gene in pancreatic adenocarcinomas.
Pancreas 30:40-45 (2005) -
Michl P, Ramjaun A, Poulsom R, Corrado D´Arrigo, Downward J.
CUTL1 - Target of TGFbeta and proteinkinase A and modulator of cancer cell migration and invasion.
Cancer Cell 7(6):521-32 (2005)
Prof. Dr. med. D.K. Bartsch
Prof. Dr. med. T. Gress
